Pivotal Phase III studies evaluating the prospect of the investigational antibiotic.

The primary endpoint was a medical cure price 28 to 35 times after randomization . Also, ceftazidime-avibactam was effective in treating cIAI patients infected with ceftazidime-resistant bacteria. The most commonly reported adverse events for ceftazidime-avibactam in combination with metronidazole had been diarrhea, nausea, fever and vomiting. We are very pleased by these results, which support the potential of ceftazidime-avibactam as a new treatment option for sufferers with these significant and life-threatening intra-abdominal attacks, said David Nicholson,PhD, Senior Vice President, Actavis Global Brands R&D. As a result of limited available options, infections because of antibiotic resistant Gram-negative bacteria are becoming more difficult to treat increasingly.‘A supramalleolar osteotomy can be used to treat lateral and anterior ankle impingement in adult individuals presenting with an overcorrected clubfoot deformity,’ the team concludes. ‘However, to achieve good outcomes, a concomitant flatfoot deformity frequently simultaneously needs to be addressed.’ The researchers conclude that ‘the results of the present study emphasize that arthrodesis, which may lead to a high rate of adjacent-joint arthritis in these sufferers could be avoided in the treating this painful deformity.’ Certified from medwireNews with permission from Springer Healthcare Ltd.