All of the efficacy analyses were carried out in the intention-to-treat population. We estimated that 206 progression events would provide the research with at least 95 percent capacity to detect a hazard ratio for death or progression of disease of 0.55, with an alpha level of 0.05 . Progression-free survival was thought as the time between the date of randomization and the day of the 1st documented event of disease progression or death, whichever occurred first according to the assessment of the site investigator. Response rates and 95 percent self-confidence intervals are reported for both study groups. Distinctions in the response rate between your two treatment groupings were tested with the use of a chi-square test with Schouten correction.Following the validity of the assay was established , AR-V7 positivity was defined as detection of the AR-V7 transcript by means of a quantitative RT-PCR assay at 36 or fewer PCR cycles, corresponding to recognition of one or more copies of AR-V7 complementary DNA as dependant on the relationship between cycle number and serial dilutions of prequantified AR-V7 . Patient Characteristics From December 2012 through September 2013, we prospectively enrolled 62 sufferers with detectable circulating tumor cells, of whom 31 received enzalutamide and 31 received abiraterone .
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