They speculated that the cold, rather than hypoxia, may be the main environmental aspect that drives the adaptive development of pika leptin. This study is published in the January 23 problem of PLoS ONE. The reduced hypoxia and temperature will be the two most memorable climatic characteristics of the Plateau. During evolution, pikas have become extremely hypoxic – and low temperature-tolerant mammals with markedly high resting metabolic rates, non-shivering thermogenesis, and a high ratio of oxygen utilization to cope with the hypoxic and cold plateau environment.An additional 294 patients in the rivaroxaban group and 278 in the enoxaparin group had been excluded from the per-protocol analysis. The total numbers of sufferers included in each one of the analysis populations are given in Desk S4 in the Supplementary Appendix. Efficacy Outcomes In the entire day 10 analysis of data from the per-protocol population, 78 of 2938 patients in the rivaroxaban group and 82 of 2993 patients in the enoxaparin group had a main outcome event, with rivaroxaban conference the prespecified criterion for noninferiority . In the day 35 evaluation of data from the altered intention-to-treat population, 131 of 2967 individuals in the group that received extended-duration rivaroxaban, as compared with 175 of 3057 sufferers in the group that received enoxaparin accompanied by placebo, had a major outcome event; therefore, extended-duration rivaroxaban met the conventional criterion for superiority .