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Ability to tune gene activity shall permit refined analysis for drug resistance, cancer Scientists who all built a man made gene circuit that allowed for the precise tuning of a gene's expression in yeast have got refined this new research tool to function in human cells now, according to research published online in Character Communications. ‘Using this circuit, you can change a gene from totally off to totally on and anywhere between those two extremes in each cell simultaneously. It's a nice tool if you want to know what happens at intermediate degrees of gene expression. There has been no such system so far, but now it really is available for mammalian cell research,’ said senior writer G-bor Bal-zsi, Ph.D., associate professor in The University of Texas MD Anderson Cancer Center Division of Systems Biology.